AI Article Synopsis
- In 2017, a mumps outbreak in a military barrack affected 249 service members, with seven cases confirmed through various diagnostic methods like IgM tests and PCR.
- The majority of the diagnosed cases had elevated IgG levels prior to the outbreak, and the identified mumps strain was confirmed as genotype G.
- The study found that a significant portion of service members were seronegative for mumps, emphasizing the unreliability of mumps serology as an indicator of immunity, highlighting the need for improved lab tests to better confirm immunity.
Article Abstract
In 2017, a mumps outbreak occurred in a barrack holding 249 service members. Suspected cases were evaluated with a combination of mumps IgG, IgM, viral culture, PCR and sequencing. Seven cases were diagnosed in febrile patients presenting with parotitis or orchitis. Mumps infection was confirmed by IgM or positive PCR with 5/7 cases having notable IgG levels before infection. Sequencing confirmed mumps genotype G strain. Serum from all 249 service members collected prior to the outbreak was withdrawn from the Department of Defense (DoD) Serum Repository and the IgG values of measles, mumps and rubella determined with 20.2%, 12.3% and 9.7% service members being seronegative, respectively. No specific IgG seronegativity combination predicted IgG marker levels to another virus within the same vaccine. This paper provides additional evidence that mumps serology is not a reliable surrogate for mumps immunity and that we need better laboratory correlates to confirm immunity.
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| http://dx.doi.org/10.1016/j.vaccine.2019.08.054 | DOI Listing |
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