Objective: The aim of this study was to evaluate the efficacy and safety of motherwort injection (MI, Yi mu cao) in preventing post-abortion hemorrhage and promoting uterine retraction after induced abortion surgery.
Methods: In this multi-center randomized controlled trial undertaken between September 2014 and August 2016, 408 child-bearing age women who underwent induced abortion surgery and randomly assigned to two groups: MI group who received intramuscular MI treatment (n = 207) and no-treatment group (n = 201). The volume of vaginal bleeding and its duration were used as primary end points; and uterine size and dimension were measured as secondary end points. Blood coagulation indices, routine blood and adverse events were recorded to evaluate the safety.
Results: The efficacy analysis was based on 366 patients. No significant difference were found in baseline characteristics between the two groups (P > 0.05). The amount of vaginal bleeding and duration of bleeding were significantly reduced in MI group compared with on-treatment group in Full Analysis Set (FAS) and Per Protocol Set (PPS) populations (P < 0.001). The volume and perimeter of the uterine dimensions in MI group were smaller than no-treatment group (P < 0.001). No significant abnormal vital signs were observed. Only 1 case of mild, transient erythema was found in MI group.
Conclusions: MI could reduce post-abortion hemorrhage and improve uterine retraction in women undergoing surgical induced abortion, without serious adverse events. It was a safe and effective treatment in preventing post-abortion hemorrhage after induced abortion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.explore.2019.08.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS).
Sci Rep
January 2025
Department of pharmacy, Heze University, Heze, 274000, Shandong Province, China.
Progestogens commonly used in the clinic include levonorgestrel, etonogestrel, medroxyprogesterone, hydroxyprogesterone, progesterone, desogestrel, and megestrol. Progestogens are widely used for contraception and the treatment of endometriosis, threatened abortion and other diseases. However, the correlation between progestogen use and depression is not clear.
View Article and Find Full Text PDFNo-Test Telehealth Medication Abortion Services Provided by US-Based Clinicians in 21 States and the District of Columbia, 2020‒2022.
Am J Public Health
February 2025
Emily M. Godfrey and Anna E. Fiastro are with the School of Medicine, Department of Family Medicine, University of Washington, Seattle. Erin K. Thayer is with the Department of Family Medicine, Keck School of Medicine of the University of Southern California, Los Angeles. Rebecca Gomperts is with Aid Access, Amsterdam, the Netherlands. Sophia M. Orlando is a student at the University of Washington School of Medicine. Caitlin K. Myers is with Middlebury College, Middlebury, VT.
To evaluate the association between distance from closest abortion facility and number of fulfilled requests through no-test telehealth medication abortion (NTMA) asynchronous service. Using deidentified 2020-2022 electronic medical record data from Aid Access users in US states where NTMA is prescribed by US-based clinicians, we describe individual user demographics and their resident county characteristics. We conducted a county-level geospatial analysis of distance to abortion facility (Myers Abortion Facility Database) on fulfilled requests using Poisson regression.
View Article and Find Full Text PDFPrevalence and determinants of pregnancy termination for childbearing women using the modified Poisson regression model: a cross-sectional study of the Tanzania Demographic and Health Survey (TDHS) 2022.
BMC Public Health
January 2025
Department of Statistics, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.
Background: Termination of pregnancy continues to be one of the major public health problems. The prevalence and determinants associated with pregnancy termination among women from low-middle income countries such as Tanzania have previously not been thoroughly investigated. Therefore, this study aims to explore the prevalence and determinants associated with pregnancy termination among Tanzanian women.
View Article and Find Full Text PDF"To Be or Not to Be" a Conscientious Objector to Voluntary Abortion: An Italian Web-Survey of Healthcare Workers.
Medicina (Kaunas)
December 2024
Department of Translational Medicine, University of Piemonte Orientale, Gynecology and Obstetrics, 'Maggiore della Carità' Hospital, 28100 Novara, Italy.
: Conscientious objection to voluntary abortion remains a hot debate topic. This could affect the accessibility to pregnancy termination. Our aim is to evaluate the possible aspects related to an operators' choice about objection for voluntary abortion, such as the following: the abolition of the time limit, the instruction of a multi-collegiate commission, the introduction of pharmacological rather than surgical procedures, the fetal/maternal illness and the case of sexual violence.
View Article and Find Full Text PDFLifetime Practice and Intention to Use Contraception After Induced Abortion Among Serbian Women in Belgrade.
Medicina (Kaunas)
November 2024
Clinic for Obstetrics and Gynecology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
: The issue of high rates of abortion among Serbian women has been previously highlighted, yet its social underpinnings are still not clear. The aim of this study was to investigate the lifetime use of and intention to use contraception among women after having an abortion. : A cross-sectional study was carried out from 2022 to 2024 at the Clinic for Obstetrics and Gynecology, University Clinical Center of Serbia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!