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Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.
Int J Dermatol
December 2024
HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.
Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.
Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.
Big brother or big opportunity? Utilization of EHR use metadata in the inpatient setting: A mixed methods study at 16 organizations.
J Hosp Med
December 2024
Division of Hospital Medicine, University of Kentucky, Lexington, Kentucky, USA.
Background: Clinician electronic actions within the electronic health record (EHR) are captured seamlessly in real-time during regular work activities in all major EHRs. Analysis of this EHR use metadata, such as audit log data, is increasingly used to understand the impact of work design on critical patient, workforce, and organizational outcomes.
Objective: Understand experiences and perspectives influencing the use and implementation of audit log data into practice.
Impact of Weekly Community-Based Dance Training Over 8 Months on Depression and Blood Oxygen Level-Dependent Signals in the Subcallosal Cingulate Gyrus for People With Parkinson Disease: Observational Study.
JMIRx Med
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Connected Minds: Neural and Machine Systems for a Healthy, Just Society, York University, Toronto, ON, Canada.
Background: Dance has emerged as a complementary treatment that may promote adaptive neural plasticity while improving symptoms of Parkinson disease (PD), such as balance, gait, posture, and walking. Understanding brain changes that arise from participation in dance interventions is important as these neural plastic changes play an important role in protecting and healing the brain. Although dance has been shown to improve PD motor and nonmotor symptoms, the neural mechanisms underlying these changes, specifically depression and mood, remain elusive.
View Article and Find Full Text PDFSocial isolation profiles and conditional process analysis among postoperative enterostomy patients with colorectal cancer.
BMC Psychol
December 2024
School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Purpose: This study aimed to identify social isolation latent profiles and analyze the specific mechanisms in which social support, resilience, and posttraumatic growth associated social isolation from the perspective of positive psychology. Suggestions were offered to improve the mental health status of postoperative enterostomy patients with colorectal cancer.
Methods: This was a cross-sectional survey.
[Survey on the Size of Oral Anticancer Drugs].
Gan To Kagaku Ryoho
December 2024
Dept. of Pharmacy, Tokyo Metropolitan Bokutoh Hospital.
Oral anticancer drugs are standard treatments for many cancers and are expected to remain widely used. Owing to the super-aged nature of the Japanese society, the number of elderly patients with cancer is rapidly increasing. Poor adherence to oral medications owing to physical limitations and swallowing difficulties in elderly patients with cancer is a major problem affecting treatment.
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