We study a spatial network model with exponentially distributed link lengths on an underlying grid of points, undergoing a structural crossover from a random, Erdős-Rényi graph, to a d-dimensional lattice at the characteristic interaction range ζ. We find that, whilst far from the percolation threshold the random part of the giant component scales linearly with ζ, close to criticality it extends in space until the universal length scale ζ^{6/(6-d)}, for d<6, before crossing over to the spatial one. We demonstrate the universal behavior of the spatiotemporal scales characterizing this critical stretching phenomenon of mean-field regimes in percolation and in dynamical processes on d=2 networks, and we discuss its general implications to real-world phenomena, such as neural activation, traffic flows or epidemic spreading.
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http://dx.doi.org/10.1103/PhysRevLett.123.088301 | DOI Listing |
Small
January 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, Stem Cells and Tissue Engineering Manufacture Center, School of Life Science, Hubei University, Wuhan, Hubei, 430062, China.
Recent advances in drug design and compound synthesis have highlighted the increasing need for effective methods of toxicity evaluation. A specialized force sensor, known as the light wavelength-encoded "Chinese guzheng" is developed. This innovative sensor is equipped with optical fiber strings and utilizes a wavelength-encoded fiber Bragg grating (FBG) that is chemically etched to reduce its diameter.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina, United States.
Purpose: To study the roles of tubulin acetylation and cyclic mechanical stretch (CMS) in trabecular meshwork (TM) cells and their impact on outflow pathway physiology and pathology.
Methods: Primary TM cell cultures were subjected to CMS (8% elongation, 24 hours), and acetylated α-tubulin at lysine 40 (Ac-TUBA4) was assessed by western blotting and immunofluorescence. Enzymes regulating tubulin acetylation were identified via siRNA-mediated knockdowns of ATAT1, HDAC6, and SIRT2.
PLoS One
January 2025
Psychology Department, Rutgers, The State University of New Jersey, Newark, NJ, United States of America.
Aphasia, a communication disorder caused primarily by left-hemisphere stroke, affects millions of individuals worldwide, with up to 70% experiencing significant reading impairments. These deficits negatively impact independence and quality of life, highlighting the need for effective treatments that target the cognitive and neural processes essential to reading recovery. This Randomized Clinical Trial (RCT) aims to test the efficacy of a combined intervention incorporating aerobic exercise training (AET) and phono-motor treatment (PMT) to enhance reading recovery in individuals with post-stroke aphasia.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
MOE Key Laboratory of Bio-Intelligent Manufacturing, Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116023, PR China. Electronic address:
Surfaces capable of specific biomolecule recognition are essential for cancer theranostics, biosensing, and tissue engineering. However, current grafting methods, critical for dictating the recognition efficiency and biocompatibility of biomaterials, especially hydrophilic polymers, struggle to balance high grafting density with ease of implementation. In pursuit of a simple, effective, and versatile solution, we introduced a polydopamine (PDA)-assisted Ca-mediated grafting strategy using hyaluronic acid (HA) as a model material.
View Article and Find Full Text PDFJ Allergy Clin Immunol
January 2025
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN; Department of Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN. Electronic address:
Background: Human monoclonal IgE antibodies recognizing peanut allergens have recently become available, but we lack a detailed understanding of how these IgEs target allergens.
Objective: To determine the molecular details of the antibody-allergen interaction for a panel of clinically important human IgE monoclonal antibodies and to develop strategies to disrupt disease causing antibody-allergen interactions.
Methods: We identified candidates from a panel of epitope binned human IgE monoclonals that recognize two important and homologous peanut allergens, Ara h 2 and Ara h 6.
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