Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence.

One-step cyclization of a tetraazamacrocycle with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, , has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor () values of 0.285 (Δ = 1) for and 0.241 (Δ = 1) for in buffer solutions were recorded.