Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917958 | PMC |
| http://dx.doi.org/10.1002/anie.201908939 | DOI Listing |
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