3384 patients over 40 years old referred to our Cardiovascular Laboratory for overt cardiovascular complaints were examined by usual non-invasive investigations. Painless myocardial ischemia (PMI) prevalence was 17.49% and degenerative aortic and mitral valvulopathies incidence was 15.60%. PMI predominate in women especially in the group 50-59 years of age in which painful forms of ischemic heart disease have the highest prevalence in men. Although more affected by painless myocardial ischemia, women show a more favourable outcome than men. Ischemic heart disease was frequently associated with isolated mitral regurgitation. In the elderly patients mitral valvulopathy was associated with calcific aortic stenosis. No significant difference was noted between mitral and aortic valvulopathies prevalence.
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Biomaterials
January 2025
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA. Electronic address:
Direct pacing of the mid myocardium where re-entry originates can be used to prevent ventricular arrhythmias and circumvent the need for painful defibrillation or cardiac ablation. However, there are no pacing electrodes small enough to navigate the coronary veins that cross these culprit scar regions. To address this need, we have developed an injectable ionically conductive hydrogel electrode that can fill the epicardial coronary veins and transform them into flexible electrodes.
View Article and Find Full Text PDFChaos
January 2025
School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China.
Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic mechanism proposed here focuses ultrasound on a cardiac tissue, controls endogenous stretch-activated Piezo1 ion channels on the focal region's cardiomyocyte sarcolemma, and restores normal heart rhythm.
View Article and Find Full Text PDFBiomed Mater
November 2024
Beijing Anzhen Hospital Affiliated to Capital Medical University, Coronary Heart Disease Surgery Center Zone 1, Beijing, People's Republic of China.
Early thrombosis following coronary artery bypass grafting (CABG) surgery leads to perioperative myocardial infarction, which causes difficulties for clinicians and patients. Moreover, once perioperative myocardial infarction occurs, the mortality rate is extremely high. In recent years, microneedle (MN) drug delivery systems have become a research hotspot with broad clinical application prospects.
View Article and Find Full Text PDFUnlabelled: Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are a promising treatment for myocardial infarction, but their therapeutic efficacy is limited by inefficient accumulation at the target site. A non-invasive MSC EV therapy that enhances EV accumulation at the disease site and extends EV retention could significantly improve post-infarct cardiac regeneration. Here we show that EVs decorated with the next-generation of high-affinity heterodimerizing leucine zippers, termed high-affinity (HiA) Zippersomes, amplify targetable surface areas through in situ crosslinking and exhibited ∼7-fold enhanced accumulation within the infarcted myocardium in mice after three days and continued to be retained up to day 21, surpassing the performance of unmodified EVs.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2024
Neurological Rehabilitation Center, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing.
Ischemic stroke refers to ischemic necrosis or softening of localized brain tissue. Transcranial magnetic stimulation (TMS) is a painless, noninvasive and green treatment method, which acts on the central nervous system through a pulsed magnetic field to assist in the treatment of central nervous system injury diseases. However, the role of Il1r2 and Tnfrsf12a in this is unknown.
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