RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
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Article Synopsis
- The study investigates the role of transcription factors Runx3, Brn3a, and Isl1 in the development of sensory proprioceptive neurons, highlighting the serious impact of Runx3 deficiency on neuron survival and motor function.
- The researchers used RNA sequencing and genomic techniques to analyze the interactions and binding sites of these transcription factors in TrkC neurons.
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