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Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia. | LitMetric
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Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.

Brian M Barth Weiyuan Wang Paul T Toran Todd E Fox Charyguly Annageldiyev Regina M Ondrasik Nicole R Keasey Timothy J Brown Viola G Devine Emily C Sullivan Andrea L Cote Vasiliki Papakotsi Su-Fern Tan Sriram S Shanmugavelandy Tye G Deering David B Needle Stephan T Stern Junjia Zhu Jason Liao Aaron D Viny

Blood Adv

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.

Published: September 2019

Distinct sphingolipid metabolism of AML with MDS-related changes defines unique sensitivity to nanoliposomal C6-ceramide. Vinblastine alters sphingolipid metabolism to enhance the sensitivity of AML to nanoliposomal C6-ceramide.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737412PMC
http://dx.doi.org/10.1182/bloodadvances.2018021295DOI Listing

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