High expression of gene encoding acute phase protein, alpha1-antitrypsin (AAT), is associated with various tumors. We sought to examine the significance of and AAT protein in non-small-cell lung cancer (NSCLC) patients and NSCLC cell lines. Tumor and adjacent non-tumor lung tissues and serum samples from 351 NSCLC patients were analyzed for expression and AAT protein levels. We also studied the impact of expression and AAT protein on H1975 and H661 cell behavior, . Lower expression in tumor but higher in adjacent non-tumor lung tissues ( = 351, = 0.016) as well as higher serum levels of AAT protein ( = 170, = 0.033) were associated with worse survival rates. Specifically, in NSCLC stage III patients, higher blood AAT levels (>2.66 mg/mL) correlated with a poor survival ( = 0.002). Intriguingly, levels of serum AAT do not correlate with levels of C-reactive protein, neutrophils-to-leukocyte ratio, and do not correlate with expression or AAT staining in the tumor tissue. Additional experiments revealed that external AAT and/or overexpressed gene significantly improve cancer cell migration, colony formation and resistance to apoptosis. gene and AAT protein play an active role in the pathogenesis of lung cancer and not just reflect inflammatory reaction related to cancer development.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770941PMC
http://dx.doi.org/10.3390/cancers11091306DOI Listing

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