AI Article Synopsis
- The study aimed to assess the prognostic significance of CTLA-4 expression and platelet lymphocyte ratio (PLR) levels in patients with esophageal squamous cell carcinoma (ESCC).
- A total of 84 ESCC patients who underwent surgery were analyzed to understand how these biomarkers related to their survival and disease characteristics.
- While high levels of CTLA-4 and PLR didn't show significant prognostic value, patients with low levels of both markers exhibited longer overall survival, highlighting the potential importance of this combined analysis for better patient outcomes.
Article Abstract
Objective: The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients.
Methods: 84 ESCC patients who received surgical treatment in our hospital were enrolled in the study. The correlation of each biomarker's level with ESCC patients' clinicopathological characteristics and overall survival (OS) was assessed.
Results: The elevated expression rate of T-CTLA-4 (tumor cell CTLA-4) and I-CTLA-4 (interstitial lymphocyte CTLA-4) was 48.8% and 44.0%, respectively. The number of enrolled patients with a higher PLR level (≥119) was 48. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. However, patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS ( = 0.023) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was also confirmed in multivariate analyses ( = 0.027).
Conclusion: These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710793 | PMC |
| http://dx.doi.org/10.1155/2019/1601072 | DOI Listing |
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