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| http://dx.doi.org/10.1523/JNEUROSCI.0656-19.2019 | DOI Listing |
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REM sleep remains paradoxical: sub-states determined by thalamo-cortical and cortico-cortical functional connectivity.
J Physiol
October 2024
Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center, INSERM U1028; CNRS, UMR5292, Université Claude Bernard, Bron, France.
During paradoxical sleep (PS, aka REM sleep) the cerebral cortex displays rapid electroencephalographic activity similar to that of wakefulness, whereas in the posterior associative thalamus, rapid activity is interrupted by frequent periods of slow-wave (delta) oscillations at 2-3 Hz, thereby dissociating the intrinsic frequency in thalamus and cortex. Here we studied the functional consequences of such a dissociation using intrathalamic and intracortical recordings in 21 epileptic patients, applying coherence analysis to examine changes in functional connectivity between the posterior thalamus (mainly medial pulvinar) and six cortical functional networks, and also between each cortical network with respect to the others. Periods of slow-wave thalamic activity ('delta PS') were more prevalent than phases of 'rapid PS,' and the delta/rapid thalamic alternance did not overlap with the classical tonic/phasic dichotomy based on rapid eye movements.
View Article and Find Full Text PDFLow thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline.
Front Psychiatry
September 2023
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, United States.
Introduction: Subjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying neurobiology of SCD is not completely understood. Since executive function may be affected earlier than memory function in the progression of AD, we aimed to characterize SCD symptoms in terms of fMRI brain activity during the computerized digit-symbol substitution task (DSST), an executive function task.
View Article and Find Full Text PDFCerebellar and basal ganglia motor network predicts trait depression and hyperactivity.
Front Behav Neurosci
September 2022
Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.
In the human brain, the cerebellum (CB) and basal ganglia (BG) are implicated in cognition-, emotion-, and motor-related cortical processes and are highly interconnected, both to cortical regions separate, trans-thalamic pathways and to each other subcortical disynaptic pathways. We previously demonstrated a distinction between cognitive and motor CB-BG networks (CCBN, MCBN, respectively) as it relates to cortical network integration in healthy young adults, suggesting the subcortical networks separately support cortical networks. The CB and BG are also implicated in the pathophysiology of schizophrenia, Parkinson's, and compulsive behavior; thus, integration within subcortical CB-BG networks may be related to transdiagnostic symptomology.
View Article and Find Full Text PDFTrans-thalamic Pathways: Strong Candidates for Supporting Communication between Functionally Distinct Cortical Areas.
J Neurosci
September 2019
Institute of Neuroscience and Medicine (INM-6), Computational and Systems Neuroscience and Institute for Advanced Simulation (IAS-6), Theoretical Neuroscience and JARA-Institut Brain Structure-Function Relationships (INM-10) 52428.
A Sensorimotor Pathway via Higher-Order Thalamus.
J Neurosci
January 2019
Department of Neurobiology, University of Chicago, Chicago, Illinois 60637
We now know that sensory processing in cortex occurs not only via direct communication between primary to secondary areas, but also via their parallel cortico-thalamo-cortical (i.e., -thalamic) pathways.
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