Sixteen new prenylated flavonoids, sinoflavonoids P-Z (-) and sinoflavonoids NA-NE (-), were isolated from the fruit of , along with eight known analogues (-). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, H-NMR, C-NMR, HSQC, HMBC). The cytotoxic activities of compounds -, , and were evaluated by MTT assay. Compound showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC values of 6.25 and 3.83 μM, respectively.
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http://dx.doi.org/10.3390/molecules24173196 | DOI Listing |
Phytochemistry
March 2024
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Investigation on the chemical constituents of Artemisia scoparia resulted in the isolation of sixteen compounds, including undescribed six pairs of diprenylated phenolic enantiomers (±)-scopacoumaricin A-F, and two pairs of cis-trans isomers cis/trans-scopacoumaricin G and cis/trans-artepillin A. Trans-artepillin A was obtained from this plant for the first time. The structures of the isolates were proposed by analysis of their 1D, 2D-NMR and HRESIMS spectroscopic data.
View Article and Find Full Text PDFCurr Drug Discov Technol
July 2023
Laboratory of Pharmacology-Toxicology, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
Aim: The prenyl-binding protein, phosphodiesterase-δ (PDEδ), is essential for the localization of prenylated KRas to the plasma membrane for its signaling in cancer.
Introduction: The general objective of this work was to develop virtually new potential inhibitors of the PDEδ protein that prevent Ras enrichment at the plasma membrane.
Methods: All computational molecular modeling studies were performed by Molecular Operating Environment (MOE).
Zhongguo Zhong Yao Za Zhi
August 2021
School of Pharmacy, Shenyang Medical College Shenyang 110034, China.
This study explored the chemical constituents of the aerial part of Hypericum curvisepalum. Sixteen compounds were isolated from the 95% ethanol extract of H. curvisepalum with various chromatographic techniques, including a new prenylated phenyl polyketide, mysorenone D(1).
View Article and Find Full Text PDFBioorg Chem
September 2021
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address:
Investigation of chemical constituents of Masclura tricuspidata leaves resulted in the isolation of 47 isoflavonoids possessing prenyl groups with different numbers and structures. Among them, sixteen compounds named cudracusisoflavones A-P (1-16) were first isolated from nature. The isoflavonoids isolated from M.
View Article and Find Full Text PDFJ Agric Food Chem
June 2021
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, P. R. China.
Sixteen metabolites, including seven C-alkylated salicylaldehyde derivatives (-) and nine prenylated indole alkaloids (-), three of which are new, namely, asperglaucins A and B ( and ) and neoechinulin F (), were separated from the endolichenic fungus SQ-8. Asperglaucin A () represents an unusual phthalide-like derivative with a benzo[]thiophen-1(3)-one scaffold. All compounds were assessed for antibacterial, antineuroinflammatory, and antioxidant activities.
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