Objective: To present the technical design and demonstrate the feasibility of a multi-channel on-scalp magnetoencephalography (MEG) system based on high critical temperature (high-[Formula: see text]) superconducting quantum interference devices (SQUIDs).
Methods: We built a liquid nitrogen-cooled cryostat that houses seven YBCO SQUID magnetometers arranged in a dense, head-aligned array with minimal distance to the room-temperature environment for all sensors. We characterize the performance of this 7-channel system in terms of on-scalp MEG utilization and present recordings of spontaneous and evoked brain activity.
Results: The center-to-center spacing between adjacent SQUIDs is 12.0 and 13.4 mm and all SQUIDs are in the range of 1-3 mm of the head surface. The cryostat reaches a base temperature of ∼ 70 K and stays cold for 16 h with a single 0.9 L filling. The white noise levels of the magnetometers is 50-130 fT/Hz at 10 Hz and they show low sensor-to-sensor feedback flux crosstalk ( 0.6%). We demonstrate evoked fields from auditory stimuli and single-shot sensitivity to alpha modulation from the visual cortex.
Conclusion: All seven channels in the system sensitively sample neuromagnetic fields with mm-scale scalp standoff distances. The hold time of the cryostat furthermore is sufficient for a day of recordings. As such, our multi-channel high-[Formula: see text] SQUID-based system meets the demands of on-scalp MEG.
Significance: The system presented here marks the first high-[Formula: see text] SQUID-based on-scalp MEG system with more than two channels. It enables us to further explore the benefits of on-scalp MEG in future recordings.
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| http://dx.doi.org/10.1109/TBME.2019.2938688 | DOI Listing |
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