AI Article Synopsis
- Hybrid materials like Mesoporous Silica Nanoparticles (MSN) are gaining popularity in Drug Delivery Systems (DDS) due to their biocompatibility, high surface area, and tunable chemistry.
- Light is highlighted as an effective external stimulus for drug release because of its precision and non-invasive nature, with azobenzenes being key components in many new DDS designs.
- The review discusses recent advancements in using light for drug delivery, focusing on the chemistry, photophysical properties, and supramolecular interactions of azobenzenes that are often overlooked.
Article Abstract
Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.
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| http://dx.doi.org/10.2174/1389557519666190904145355 | DOI Listing |
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