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| http://dx.doi.org/10.1021/acscentsci.9b00675 | DOI Listing |
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The Mystical Experience Questionnaire 4-Item and Challenging Experience Questionnaire 7-Item.
Psychedelic Med (New Rochelle)
March 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: The Mystical Experience Questionnaire (MEQ-30) and Challenging Effects Questionnaire (CEQ) are two of the most widely used, validated instruments to probe subjective effects of psychedelic drugs. However, these assessments are lengthy and can be a burden to study participants or patients if administered during acute psychedelic effects, after resolution of psychedelic effects when participants are often fatigued, or in studies with multiple other assessments. The development of briefer measures can advance research and patient assessment.
View Article and Find Full Text PDFAcute Subjective Experiences of Intravenous Ketamine Therapy Among Medically Hospitalized Patients with Alcohol Use Disorder.
Psychedelic Med (New Rochelle)
June 2024
Department of Behavioral Health, Denver Health & Hospital Authority, Denver, Colorado, USA.
Introduction: Alcohol use disorder (AUD) is widespread and problematic in the United States, and current pharmacotherapy options have relatively modest effects. Therefore, novel interventions such as ketamine therapy have gained interest as potentially efficacious options, known to generate unique psychotherapeutic experiences. The present secondary analysis examines the acute subjective experiences-both quantitatively and qualitatively-of clinical trial participants with AUD who received intravenous (IV) ketamine therapy in the hospital setting.
View Article and Find Full Text PDFAdvanced Adaptive Protein Membrane with Super-High Flux and Precise Molecular Sieving of Dyes from Salts.
Small
March 2025
State Key Laboratory of Separation Membranes and Membrane Process, School of Materials Science and Engineering, Tiangong University, Tianjin, 300387, P. R. China.
Precise separation of small organic molecules and electrolyte salts is critical for various industrial processes, necessitating advanced membranes with uniform pores. Proteins, as one typical nature polymer having the exactly same structure and molecular weight, offer a promising material for making such membranes. Here, hemoglobin (BHb) and lysozyme (Lyz) are utilized to fabricate precise nanofiltration membranes through amyloid-like co-assembly, triggered by Tris(2-carboxyethyl) phosphine.
View Article and Find Full Text PDFTumour Mutational Burden and Immune Checkpoint Inhibitor Response in Non-small Cell Lung Cancer: A Continuous Modelling Approach.
Target Oncol
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College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Background: Tumour mutational burden (TMB) is an established biomarker for patients treated with immune checkpoint inhibitors (ICIs). The optimal TMB cut-off is uncertain. It is also uncertain whether there is a sharp TMB threshold or a more graduated change in clinical outcomes as TMB increases.
View Article and Find Full Text PDFDeveloping a short form of the Awe Experience Scale (AWE-SF) in psychedelic samples.
PLoS One
December 2024
Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.
Article Synopsis
- - The study developed a shortened version of the Awe Experience Scale (AWE-SF) to make it easier for participants while keeping its accuracy intact, using data collected from psychedelic samples across five different studies.
- - The AWE-SF kept the original six-factor structure of the longer AWE-S and was validated by showing strong connections to positive emotions, mystical experiences, and overall well-being.
- - Specific elements of awe, like feelings of connection or vastness, were linked to positive feelings, while aspects like self-loss were tied to more challenging experiences; overall, the AWE-SF proved effective as a tool for measuring awe experiences.
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