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Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function. | LitMetric

Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function.

Front Neurosci

Laboratory of Neural Engineering and Rehabilitation, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, China.

Published: August 2019

AI Article Synopsis

  • - Transcranial magnetic stimulation (TMS) is being studied for its potential to treat depression, specifically exploring the effects of low-frequency pulsed magnetic fields (LFPMF) on cognitive deficits related to depression.
  • - In this study, Wistar rats subjected to chronic unpredictable stress (CUS) experienced weight loss, anhedonia, anxiety, and cognitive decline, which were evaluated alongside control groups.
  • - After 2 weeks of LFPMF treatment, the CUS group showed significant improvements in spatial cognition and synaptic function, indicating that LFPMF can effectively mitigate depressive behaviors and cognitive issues by regulating synaptic activity.

Article Abstract

Transcranial magnetic stimulation (TMS) has shown great promise as a medical treatment of depression. The effectiveness of TMS treatment at high frequency has been well investigated; however, low-frequency TMS in depression treatment has rarely been investigated in depression-induced cognitive deficits. Herein, this study was carried out to assess the possible modulatory role of low-frequency pulsed magnetic field (LFPMF) on reversing cognitive impairment in a model of depression induced by chronic unpredictable stress (CUS). Wistar rats were randomly allocated into four groups as follows: a control group (CON), a control applied with LFPMF (CON + LFPMF), a CUS group, and a CUS treated with LFPMF (CUS + LFPMF) group. During 8 weeks of CUS, compared to those in the CON group, animals not only gained less weight but also exhibited anhedonia, anxiety, and cognitive decline in behavioral tests. After 2-week treatment of LFPMF, a 20 mT, 1 Hz magnetic stimulation, it reversed the impairment of spatial cognition as well as hippocampal synaptic function including long-term potentiation and related protein expression. Thus, LFPMF has shown effectively improvements on depressant behavior and cognitive dysfunction in CUS rats, possibly via regulating synaptic function.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710372PMC
http://dx.doi.org/10.3389/fnins.2019.00820DOI Listing

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