We reported the complete nucleotide sequence of a (X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a (X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. (X4) was flanked by two IS, which may be responsible for (X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant (X4) gene.
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| http://dx.doi.org/10.1128/AAC.01373-19 | DOI Listing |
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