AI Article Synopsis
- This study investigates the properties of lutein-loaded PVA/SA nanofibers created through electrospinning, focusing on their potential biomedical uses.
- To enhance the water resistance of these nanofibers, they were cross-linked using a combination of glutaraldehyde and boric acid, and various tests were performed to analyze their characteristics.
- The findings indicate that the nanofibers can release lutein in a controlled manner over 48 hours, demonstrating sustained release that follows a non-Fickian diffusion mechanism, making them promising for drug delivery applications.
Article Abstract
This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers' water-resistant ability for potential biomedical applications, the electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and saturated boric acid solution at room temperature. The nanofibers were characterized using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle measurements testified the hydrophilicity change of the nanofibers before and after cross-linking. The lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption spectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian) release mechanism as indicated by diffusion exponent value obtained from the Korsmeyer-Peppas equation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great potential as a controlled release system.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781311 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics11090449 | DOI Listing |
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