AI Article Synopsis
- The study aimed to analyze the expression patterns of lipid metabolism genes related to intramuscular fat (IMF) deposition in Laiwu pigs' Longissimus dorsi muscle.
- Significant correlations were observed between IMF content and lipid metabolism gene expressions, with fatty acid synthase (FASN) showing the strongest positive correlation and carnitine palmitoyl transferase 1B (CPT1B) showing the strongest negative correlation.
- The research concluded that both upregulation of fat deposition genes and downregulation of fat removal genes contribute to increased IMF deposition in Laiwu pigs.
Article Abstract
Objective: The objective of this study was to measure the special expression pattern of lipid metabolism genes and investigate the molecular mechanisms underlying intramuscular fat (IMF) deposition in Longissimus dorsi muscle of Laiwu pigs.
Methods: Thirty-six pigs (Laiwu n = 18; Duroc×Landrace×Yorkshire n = 18) were used for the measurement of the backfat thickness, marbling score, IMF content, and expression of lipid metabolism genes.
Results: Significant correlations were found between IMF content and the mRNA expression of lipid metabolism genes. Of the 14 fat deposition genes measured, fatty acid synthase (FASN) showed the strongest correlation (r = 0.75, p = 0.001) with IMF content, and of the 6 fat removal genes, carnitine palmitoyl transferase 1B (CPT1B) exhibited the greatest negative correlation (r = -0.66, p = 0.003) with IMF content in Laiwu pig. Multiple regression analysis showed that CPT1B, FASN, solute carrier family 27 member 1 (SLC27A1), and fatty acid binding protein 3 (FABP3) contributed 38% of the prediction value for IMF content in Laiwu pigs. Of these four variables, CPT1B had the greatest contribution to IMF content (14%) followed by FASN (11%), SLC27A1 (9%), and FABP3 (4%).
Conclusion: Our results indicate that the combined effects of an upregulation in fat deposition genes and downregulation in fat removal genes promotes IMF deposition in Laiwu pigs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054625 | PMC |
| http://dx.doi.org/10.5713/ajas.18.0225 | DOI Listing |
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