AI Article Synopsis
- The study uses two-dimensional infrared spectroscopy to analyze how the amide and carboxylate anion groups of hyaluronan polymers interact at neutral pH.
- It identifies the presence of intrachain hydrogen bonds between these groups in aqueous solution and measures the orientation and participation of amide groups in these bonds.
- The findings suggest that varying pH or temperature does not significantly affect hydrogen bonding, indicating it does not contribute to the rigidity of hyaluronan chains, despite changes in chain length and solution viscosity.
Article Abstract
We use two-dimensional infrared spectroscopy to study the interactions between the amide and carboxylate anion groups of hyaluronan polymers at neutral pH. The spectra reveal the presence of intrachain hydrogen bonds between the amide and carboxylate anion groups in aqueous solution. We determine the relative orientation of the amide and carboxylate anion groups when forming this hydrogen bond and quantify the fraction of amide groups that participate in hydrogen bonding. We find that a variation of the pH and/or temperature has a negligible effect on this fraction, whereas the persistence length of the hyaluronan chains and the associated viscosity of hyaluronan solutions are known to change significantly. We conclude that the hydrogen bonding between the amide and carboxylate anion groups does not significantly contribute to the chain rigidity of hyaluronan polymers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767362 | PMC |
| http://dx.doi.org/10.1021/acs.jpca.9b06462 | DOI Listing |
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