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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703284 | PMC |
| http://dx.doi.org/10.1136/bmjgh-2019-001579 | DOI Listing |
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Diagnostic accuracy of Truenat MTB Plus, Truenat MTB Ultima and Xpert MTB/RIF Ultra for the diagnosis of pulmonary TB in an HIV-endemic setting.
Res Sq
September 2024
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Article Synopsis
- Truenat MTB Plus and MTB Ultima are WHO-approved tests for tuberculosis, but their performance data are limited, prompting a study in Cape Town, South Africa with 498 participants.
- The study compared the accuracy of these tests against the Xpert MTB/RIF Ultra using culture as the reference standard, revealing sensitivities of 84% for MTB Plus, 90% for Ultima, and 92% for Ultra, with varying specificities.
- While Ultima showed similar sensitivity to Ultra, both tests had significant rates of unsuccessful results and exhibited variability based on lot differences, indicating that improvements are needed in their reliability for TB detection.
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer's disease.
Alzheimers Res Ther
May 2024
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontoparietal network functional connectivity (LFPN-FC) confers resilience against beta-amyloid (Aβ)-related cognitive decline in preclinical sporadic and autosomal dominant Alzheimer's disease (AD), as well as against LC-related cognitive changes. Given that the LFPN and the LC play important roles in attention, and attention deficits have been observed early in the disease process, we examined whether LFPN-FC and LC structural health attenuate attentional decline in the context of AD pathology.
View Article and Find Full Text PDFThe Implications of PrEP Use, Condom Use, and Partner Viral Load Status for Openness to Serodifferent Partnering Among US Sexual Minority Men (SMM).
AIDS Behav
February 2024
Department of Psychological and Brain Sciences, George Washington University, 2013 H Street NW, Washington, DC, 20006, USA.
PrEP has been reported to facilitate openness to serodifferent sexual partnerships among sexual minority men (SMM). However, other aspects of a sexual scenario likely come into play, including whether or not condoms are used and whether or not the partner living with HIV has an undetectable viral load. This online survey study evaluated the association between PrEP status and openness to serodifferent partnering, as well as the effects of various sexual scenario variables (condom use and partner's viral load) among 268 HIV-negative SMM in the US.
View Article and Find Full Text PDFNurse experiences of partnership nursing when caring for children with long-term conditions and their families: A qualitative systematic review.
J Clin Nurs
March 2024
School of Nursing, Midwifery and Public Health, University of Canberra, Bruce, Australian Capital Territory, Australia.
Aim: To explore the experiences of partnership nursing among nurses when caring for children and young people with long-term conditions, and their families.
Background: Partnership nursing is promoted as a positive model of care among paediatric nurses, where shared roles and decision-making, parental participation, mutual trust and respect, communication and negotiation are valued to create positive care experiences and enhance patient outcomes. Little is known about how nurses use partnership with both the patient and the parents in this triad to deliver partnership nursing.
Microbes, the 'silent third partners' of bee-angiosperm mutualisms.
Trends Ecol Evol
January 2024
Department of Entomology, Cornell University, Comstock Hall, 2126, Ithaca, NY 14853, USA.
While bee-angiosperm mutualisms are widely recognized as foundational partnerships that have shaped the diversity and structure of terrestrial ecosystems, these ancient mutualisms have been underpinned by 'silent third partners': microbes. Here, we propose reframing the canonical bee-angiosperm partnership as a three-way mutualism between bees, microbes, and angiosperms. This new conceptualization casts microbes as active symbionts, processing and protecting pollen-nectar provisions, consolidating nutrients for bee larvae, enhancing floral attractancy, facilitating plant fertilization, and defending bees and plants from pathogens.
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