AI Article Synopsis
- Immunodeficient children are particularly susceptible to disseminated Bacillus Calmette-Guérin (BCG) infections, prompting a study of clinical manifestations of BCGosis in this group.
- A systematic review of literature from various medical databases identified 37 articles relevant to BCG vaccination and its effects on children with specific primary immunodeficiencies, excluding those focused on intravesicular BCG administration.
- The study emphasizes that disseminated BCG infection can be a first sign of underlying immunodeficiency, suggesting the need for thorough immunological assessments in affected children.
Article Abstract
Introduction: Immunodeficient children are at a high risk of disseminated Bacillus Calmette-Guérin [BCG] infection. We assessed the literature on clinical manifestations of BCGosis in children with specific primary immunodeficiencies.
Material And Methods: We conducted a systematic review of clinical practice articles by searching Medline, PubMed, Embase, Scopus, Web of Science and Google Scholar from their inception to date.
Results: Thirty-seven articles were included regarding BCG vaccination and its dissemination in children with primary immunodeficiencies. Articles on dissemination after intravesicular BCG were excluded from the study.
Conclusions: Since disseminated BCG vaccination may be the first manifestation of a primary immunodeficiency disease, a comprehensive search for immunological defects in children developing these problems after BCG vaccination seems rational.
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| http://dx.doi.org/10.5603/ARM.2019.0040 | DOI Listing |
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