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Continuous focusing, fractionation and extraction of anionic analytes in a microfluidic chip. | LitMetric

Continuous focusing, fractionation and extraction of anionic analytes in a microfluidic chip.

Lab Chip

BIOS Lab on a Chip group, MESA+ Institute for Nanotechnology, Max Planck Centre for Complex Fluid Dynamics and Technical Medical Centre, University of Twente, The Netherlands.

Published: September 2019

AI Article Synopsis

Article Abstract

Electrokinetic focusing and separation methods, specifically ion concentration polarization focusing (ICPF), provide a very powerful and easy to use analytical tool for several scientific fields. Nevertheless, the concentrated and separated analytes are effectively trapped inside the chip in picoliter volumes. In this article we propose an ICPF device that allows continuous and selective extraction of the focused analytes. A theoretical background is presented to understand the dynamics of the system and a 1D model was developed that describes the general behavior of the system. We demonstrate the selective extraction of three fluorescent model anionic analytes and we report selective extraction of the analytes at a 300-fold increased concentration.

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Source
http://dx.doi.org/10.1039/c9lc00434cDOI Listing

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