Aims: The aim of this study was to report the results of custom-made endoprostheses with extracortical plates plus or minus a short, intramedullary stem aimed at preserving the physis after resection of bone sarcomas in children.
Patients And Methods: Between 2007 and 2017, 18 children aged less than 16 years old who underwent resection of bone sarcomas, leaving ≤ 5 cm of bone from the physis, and reconstruction with a custom-made endoprosthesis were reviewed. Median follow-up was 67 months (interquartile range 45 to 91). The tumours were located in the femur in 11 patients, proximal humerus in six, and proximal tibia in one.
Results: The five-year overall survival rate was 78%. No patient developed local recurrence. The five-year implant survival rate was 79%. In all, 11 patients (61%) developed a complication. Seven patients (39%) required further surgery to treat the complications. Implant failures occurred in three patients (17%) including one patient with aseptic loosening and two patients with implant or periprosthetic fracture. The preserved physis continued to grow at mean 3.3 cm (0 to 14). The mean Musculoskeletal Society score was 88% (67% to 97%).
Conclusion: Custom-made endoprostheses that aim to preserve the physis are a safe and effective option for preserving physeal growth, limb length, and joint function with an acceptable rate of complications. Cite this article: 2019;101-B:1144-1150.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1302/0301-620X.101B9.BJJ-2018-1333.R1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary breast osteosarcoma: A case report highlighting the importance of radiologic-pathologic correlation.
Radiol Case Rep
March 2025
Department of Radiology, Sanford USD Medical Center, Sioux Falls, SD, USA.
Osteosarcoma of primary breast origin is a rare form of malignancy. Imaging findings are nonspecific and often overlap with other differential considerations reinforcing the importance of radiologic-pathologic correlation for an accurate diagnosis. This case report details the clinical presentation, imaging findings, histopathological features, and therapeutic approach that transpired to diagnose and treat this rare malignancy.
View Article and Find Full Text PDFAn annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlines.
Data Brief
February 2025
Cell Death, Lysosomes and Artificial Intelligence Group, Department of Experimental Medical Science, Faculty of Medicine, Lund University, BMC D10, 22184 Lund, Sweden.
Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be detected are cells. In order to develop and benchmark algorithms and neural networks that can perform this task, high-quality datasets with annotated cell outlines are needed.
View Article and Find Full Text PDFExploration of metastasis-related signatures in osteosarcoma based on tumor microenvironment by integrated bioinformatic analysis.
Heliyon
January 2025
Center for Plastic & Reconstructive Surgery, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, China.
Background: The present study aims to explore the metastasis-related signatures in connection with tumor microenvironment (TME), revealing new molecular targets promising in improving osteosarcoma (OS) patients' outcomes.
Methods: The high-throughput sequencing data was downloaded from the TARGET database and performed the ESTIMATE algorithm. Metastasis-related information was obtained from the GSE21257 dataset.
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter-mediated doxorubicin resistance.
J Pathol
January 2025
Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan.
Osteosarcoma is an aggressive bone malignancy with a high propensity for drug resistance and metastasis, leading to poor clinical outcomes. This study investigates the role of core 1 β1,3-galactosyltransferase 1 (C1GALT1) in osteosarcoma, focusing on its implications in chemoresistance. Our findings reveal that high expression of C1GALT1 is associated with advanced stages, adverse overall survival, and increased recurrence rates.
View Article and Find Full Text PDFSingle-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.
J Transl Med
January 2025
Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Background: Osteosarcoma is the most common malignant bone tumor in children and adolescents, characterized by high disability and mortality rates. Over the past three decades, therapeutic outcomes have plateaued, underscoring the critical need for innovative therapeutic targets. Solute carrier (SLC) family transporters have been implicated in the malignant progression of a variety of tumors, however, their specific role in osteosarcoma remains poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!