Despite the success of antiretroviral therapies, there is no cure for HIV-1 infection due to the establishment of a long-lived latent reservoir that fuels viral rebound upon treatment interruption. 'Shock-and-kill' strategies to diminish the latent reservoir have had modest impact on the reservoir leading to considerations of alternative approaches to target HIV-1 proviruses. This review explores approaches to target HIV-1 transcription as a way to block the provirus expression.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854310 | PMC |
| http://dx.doi.org/10.1016/j.coviro.2019.07.011 | DOI Listing |
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