Identifying FL11 subtype by characterizing tumor immune microenvironment in prostate adenocarcinoma via Chou's 5-steps rule.

Prostate cancer is one of the leading causes of death in men worldwide, revealing a substantial heterogeneity in terms of molecular and clinical behaviors. Tumor infiltrating immune cell is associated with prognosis and response to immunotherapy in several cancer types. However, until now, the immune infiltrate profile of distinct subtypes for prostate cancer remains poorly characterized. In this study, using immune infiltration profiles as well as transcriptomic datasets, we characterized this subtype of prostate tumors. We observed that the FLI1 subtype of prostate tumors was highly enriched in immune system processes, immune related KEGG pathways and biological processes. We also expanded this approach to explore the immune infiltration profile of the high FLI1 expression subtype for skin cutaneous melanoma, similar results were found. Investigation of the association of immune infiltration features with the FLI1 expression demonstrated that many important features were associated with the FLI1 expression.