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Feasibility study of patient-specific four-dimensional in vivo tracking system for high-dose-rate brachytherapy: Experimental evaluation.
Med Phys
January 2025
Department of Radiation Oncology, Inha University Hospital, Incheon, Republic of Korea.
Background: High-dose-rate (HDR) brachytherapy using Iridium-192 as a radiation source is widely employed in cancer treatment to deliver concentrated radiation doses while minimizing normal tissue exposure. In this treatment, the precision with which the sealed radioisotope source is delivered significantly impacts clinical outcomes.
Purpose: This study aims to evaluate the feasibility of a new four-dimensional (4D) in vivo source tracking and treatment verification system for HDR brachytherapy using a patient-specific approach.
Lipid Nanoparticles Enable Efficient In Vivo DNA Knock-In via HITI-Mediated Genome Editing.
Biomolecules
December 2024
Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka, Japan.
In vivo genome editing holds great therapeutic potential for treating monogenic diseases by enabling precise gene correction or addition. However, improving the efficiency of delivery systems remains a key challenge. In this study, we investigated the use of lipid nanoparticles (LNPs) for in vivo knock-in of ectopic DNA.
View Article and Find Full Text PDFQuantum implementation of the classical guided image filtering algorithm.
Sci Rep
January 2025
School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Image filtering involves the application of window operations that perform valuable functions, such as noise removal, image enhancement, high dynamic range (HDR) compression, and so on. Guided image filtering is a new type of explicit image filter with multiple advantages. It can effectively remove noise while preserving edge details, and can be used in a variety of scenarios.
View Article and Find Full Text PDFAutomatic X-ray teeth segmentation with grouped attention.
Sci Rep
January 2025
The University of New South Wales, Sydney, Australia.
Detection and teeth segmentation from X-rays, aiding healthcare professionals in accurately determining the shape and growth trends of teeth. However, small dataset sizes due to patient privacy, high noise, and blurred boundaries between periodontal tissue and teeth pose challenges to the models' transportability and generalizability, making them prone to overfitting. To address these issues, we propose a novel model, named Grouped Attention and Cross-Layer Fusion Network (GCNet).
View Article and Find Full Text PDFEscalating the dose of high-dose-rate brachytherapy combined with external beam radiotherapy improves the disease control rate in patients with high- or very-high-risk prostate cancer.
Brachytherapy
December 2024
Department of Radiology, Wakayama Medical University, Wakayamashi, Wakayama, Japan.
Purpose: High-dose-rate brachytherapy (HDR-BT) combined with external beam radiotherapy (EBRT) is an effective treatment for patients with high- and very-high-risk prostate cancer. We sought to identify the factors associated with reduced biochemical recurrence rates following HDR-BT.
Methods: A total of 304 patients with high- or very-high-risk prostate cancer who underwent HDR-BT and EBRT were analyzed.
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