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Dynamics of the prognostic index during the course of treatment for anaplastic thyroid carcinoma.
Surg Today
January 2025
Department of Endocrine Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Purpose: Tumor/node/metastasis staging and prognostic index (PI) are used to predict prognosis and guide treatment for anaplastic thyroid carcinoma (ATC). With the advent of treatments, such as BRAF/MEK inhibitors and immune checkpoint inhibitors, dynamic markers to assess disease status and treatment efficacy are needed. This study examined the utility of PI as a dynamic marker for ATC treatment.
View Article and Find Full Text PDFBurn-induced mitochondrial dysfunction in hepatocytes: The role of methylation-controlled J protein silencing.
J Trauma Acute Care Surg
January 2025
From the Division of Gastrointestinal, Trauma, and Endocrine Surgery, Department of Surgery (A.P., K.M.M., A.C.Q., E.J.K., J.-P.I.), Division of Burn Research (E.J.K.), and Division of Alcohol Research (E.J.K.), Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado.
Background: Burn injuries trigger a systemic hyperinflammatory response, leading to multiple organ dysfunction, including significant hepatic damage. The liver plays a crucial role in regulating immune responses and metabolism after burn injuries, making it critical to develop strategies to mitigate hepatic impairment. This study investigates the role of methylation-controlled J protein (MCJ), an inner mitochondrial protein that represses complex I in burn-induced oxidative stress and mitochondrial dysfunction, using an in vitro Alpha Mouse Liver 12 cell model.
View Article and Find Full Text PDFAssociation Between Serum Antinuclear Antibody and Polycystic Ovarian Syndrome in Reproductive Women Aged 18 to 35 Years: A Quest for an Autoimmune Marker.
Cureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences, Raipur, IND.
Introduction: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrinal physiological disorder characterized by chronic oligo-ovulation or an-ovulation, hyperandrogenism, and polycystic morphology in ovaries on transvaginal or abdominal ultrasound. Hyperandrogenism and insulin resistance are already well-documented pathophysiological mechanisms in PCOS. Besides this, autoimmunity has been hypothesized in its pathogenesis.
View Article and Find Full Text PDFParaneoplastic endocrine syndromes: a contemporary overview.
Expert Rev Endocrinol Metab
January 2025
Carrera de Medicina Humana, Universidad Científica del Sur, Lima, Perú.
Introduction: Endocrine paraneoplastic syndromes (ePNS) are caused by malignant cells that induce hormonal alterations unrelated to the tissue of origin of the neoplasm. The aim of this manuscript is to review the pathophysiology, diagnosis, and treatment of endocrine paraneoplastic syndromes (ePNS).
Areas Covered: We searched the PubMed/Medline, Embase, and Scielo databases, including 96 articles.
Developmental Programming: Sex-specific Effects of Prenatal Exposure to a Real-Life Mixture of Environmental Chemicals on Liver Function and Transcriptome in Sheep.
Environ Pollut
January 2025
Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Humans are chronically exposed to a mixture of environmental chemicals (ECs), many with metabolic and endocrine disrupting potential, contributing to non-communicable disease burden. Understanding the effects of chronic exposure to low-level mixtures of ECs requires an animal model that reflects real-world conditions, lags behind studies on single ECs. Biosolids, from wastewater treatment, offers a real-life model to investigate the developmental health risks from EC mixtures.
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