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http://dx.doi.org/10.1016/j.yexcr.2019.111566 | DOI Listing |
Exp Cell Res
October 2019
Tissue Engineering Laboratories, Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Tatzberg 47-49, 01307, Dresden, Germany.
Exp Cell Res
October 2019
Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, 142-8555, Japan. Electronic address:
PLoS One
June 2015
Tissue Engineering Laboratories, BIOTEC, Technische Universität Dresden, Dresden, Germany.
Prominin-1 (CD133) is physiologically expressed at the apical membranes of secretory (serous and mucous) and duct cells of major salivary glands. We investigated its expression in various human salivary gland lesions using two distinct anti-prominin-1 monoclonal antibodies (80B258 and AC133) applied on paraffin-embedded sections and characterized its occurrence in saliva. The 80B258 epitope was extensively expressed in adenoid cystic carcinoma, in lesser extent in acinic cell carcinoma and pleomorphic adenoma, and rarely in mucoepidermoid carcinoma.
View Article and Find Full Text PDFInt J Mol Med
October 2010
Department of Biomedical Sciences, University of Catania, Catania, Italy.
Prominin-1 (CD133) is a pentaspan cholesterol-binding membrane glycoprotein. Chronic treatment with isoproterenol, a beta-receptor agonist, induces several dramatic effects on salivary glands, such as enhanced DNA synthesis and proliferation of salivary acinar cells. In addition, the biosynthetic pathways of membrane lipids may be altered by the isoproterenol stimulation.
View Article and Find Full Text PDFHistochem Cell Biol
November 2007
Tissue Engineering Laboratories, Biotec, University of Technology Dresden, Tatzberg 47-49, 01307, Dresden, Germany.
The major cephalic exocrine glands share many morphological and functional features and so can be simultaneously affected in certain autoimmune- and inherited disorders leading to glandular hypofunction. Phenotypic characterization of these exocrine glands is not only an interesting biological issue, but might also be of considerable clinical relevance. The major salivary and lacrimal glands might therefore be potential subjects of future cell-based regenerative/tissue engineering therapeutic approaches.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!