Five new indole-terpenoids named penerpenes E-I (-), along with seven known ones (-), were isolated from the marine-derived fungus sp. KFD28 from a bivalve mollusk, . The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Compound was assigned as an indole-diterpenoid with a unique 6/5/5/6/6/5/5 heptacyclic ring system. Compound represents an indole-diterpenoid with a new carbon skeleton derived from paxilline by the loss of three carbons (C-23/24/25). Compound contains an additional oxygen atom between C-21 and C-22 compared to paxilline to form an unusual 6/5/5/6/6/7 hexacyclic ring system bearing a 1,3-dioxepane ring, which is rarely encountered in natural products. Compounds , , , and showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC values of 14, 27, 23, and 13 μM, respectively.
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