Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.bioconjchem.9b00569 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pooled safety analysis and management of sotorasib-related adverse events in KRAS G12C-mutated advanced non-small cell lung cancer.
Oncologist
January 2025
Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Thoracic Oncology, 1066 CX Amsterdam, The Netherlands.
Introduction: We describe the safety of sotorasib monotherapy in patients with KRAS G12C-mutated advanced non-small cell lung cancer (NSCLC) and discuss practical recommendations for managing key risks.
Methods: Incidence rates of treatment-related adverse events (TRAEs) were pooled from 4 clinical trials: CodeBreaK 100 (NCT03600883), CodeBreaK 101 (NCT04185883), CodeBreaK 105 (NCT04380753), and CodeBreaK 200 (NCT04303780) and graded according to CTCAE v5.0.
Impacts of on oxygen sensitivity, gene expression, and murine infection in 630∆.
J Bacteriol
January 2025
Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
infection (CDI), characterized by colitis and diarrhea, afflicts approximately half a million people in the USA every year, burdening both individuals and the healthcare system. 630Δ is an erythromycin-sensitive variant of the clinical isolate 630 and is commonly used in the research community due to its genetic tractability. 630Δ possesses a point mutation in , an autoregulated transcriptional repressor that regulates oxidative stress resistance genes.
View Article and Find Full Text PDF(Omphalotaceae, Agaricales), A New Species from Danang, Vietnam.
Mycobiology
December 2024
Faculty of Chemical Technology and Environment, University of Technology and Education, The University of Danang, Danang, Vietnam.
During the collection of macrofungi resources in Son Tra Nature Reserve, Danang, Vietnam, two fungal specimens of the genus , designated as M34295 and M3457, living on dead still-attached branches of L. at an elevation around 360 m above the sea level were recorded. The morphological characteristics of the specimens shared some common characteristics with spp.
View Article and Find Full Text PDFComputational predictions of magnetic resonance acoustic radiation force imaging for breast cancer focused ultrasound therapy.
Int J Hyperthermia
December 2025
Department of Mechanical Engineering, Brigham Young University, Provo, UT, USA.
Purpose: In magnetic resonance-guided focused ultrasound (MRgFUS) breast therapies, the focal location must be characterized to guide successful treatment. Focal characterization is difficult because heterogeneous breast tissues introduce phase aberrations that blur and shift the focus and traditional guidance methods do not work in adipose tissues. The purpose of this work is to evaluate numerical simulations of MRgFUS that predict the focal location.
View Article and Find Full Text PDFDegradation rates and ageing effects of UV on tyre and road wear particles.
Chemosphere
January 2025
TNO Environmental Modelling, Sensing and Analysis, Princetonlaan 6-8, 3584 CB, Utrecht, the Netherlands. Electronic address:
Tyre and road wear particles (TRWPs) are estimated to be the largest source of microplastics in the environment and due to the intrinsic use of tyres in our society this will continue to grow. Understanding their degradation mechanisms and subsequent accumulation over time is important to gain insights into the fate and impact of these particles in the environment. Accelerated UV-ageing was performed on cryomilled tyre tread particles and TRWPs from a road simulator to investigate the abiotic degradation of rubber.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!