Monomeric methyl metaphosphate (CHOPO), a highly electrophilic phosphorylating intermediate in chemical oligonucleotide synthesis, has been generated in the gas phase by high-vacuum flash pyrolysis (1000 K) of methyl 2-butenylphosphonate. In addition to the unambiguous characterization using IR spectroscopy in solid N-, Ar-, and Ne-matrices, the formation CHOPO in the photooxidation of the prototypical phosphinidene oxide CHPO by O with O-isotope scrambling has been observed in the solid N-matrix (15 K).
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