Objectives: The purpose of this study was to explore the association between polymorphism in gene and type 1 diabetes (T1D).
Methods: A systematic search of studies on the association of polymorphism in gene with T1D susceptibility was conducted in PubMed, Web of science, Elsevier Science Direct, and Cochrane Library. Eventually, 9 published studies were included. The strength of association between polymorphism and T1D susceptibility was assessed by odds ratios (ORs) with its 95% confidence intervals (CIs).
Results: A total of 9 case-control studies, consisting of 5369 T1D patients and 6920 controls, were included in the meta-analysis. This meta-analysis showed significant association between polymorphism and T1D susceptibility in overall population (A vs. C, OR: 1.292, 95% CI= 1.224-1.364, =0.450, is P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity.
Conclusions: polymorphism is associated with T1D susceptibility and A allele is a risk factor for T1D. However, more large-scale studies are warranted to replicate our findings.
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| http://dx.doi.org/10.1155/2019/7689642 | DOI Listing |
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