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High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces. | LitMetric

AI Article Synopsis

  • Anti-infective surfaces utilize nanocoatings to combat infection risks associated with implants and medical devices by releasing antibacterial molecules.
  • A "layer-by-layer" (LbL) method forms a self-assembled monolayer (SAM) of silver sulfadiazine on hydroxylated surfaces, demonstrating strong antibacterial properties against multiple bacteria types.
  • The process is versatile, allowing for the creation of bactericidal nano-monolayers on various materials by applying a glass-like SiO film beforehand.

Article Abstract

Anti-infective surfaces are a modern strategy to address the issue of infection related to the clinical use of materials for implants and medical devices. Nanocoatings, with their high surface/mass ratio, lend themselves to being mono-layered on the material surfaces to release antibacterial molecules and prevent bacterial adhesion. Here, a "layer-by-layer" (LbL) approach to achieve a self-assembled monolayer (SAM) with high microbicidal effect on hydroxylated surfaces is presented, exploiting the reaction between a monolayer of thiolic functions on glass/quartz surfaces and a newly synthesized derivative of the well-known antibacterial compound silver sulfadiazine. Using several different techniques, it is demonstrated that a nano-monolayer of silver sulfadiazine is formed on the surfaces. The surface-functionalized materials showed efficient bactericidal effect against both Gram-positive and Gram-negative bacteria. Interestingly, bactericidal self-assembled nano-monolayers of silver sulfadiazine could be achieved on a large variety of materials by simply pre-depositing glass-like SiO films on their surfaces.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748069PMC
http://dx.doi.org/10.3390/ma12172761DOI Listing

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