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Preparation of Ethosome Gel with Total Flavonoids from (L.) Willd. for the Treatment of Vitiligo.
Gels
January 2025
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832002, China.
(L.) Willd. is a traditional medicinal herb in Chinese medicine, extensively used by various ethnic groups due to the numerous advantages derived from its total flavonoids.
View Article and Find Full Text PDFSegmental vitiligo: autoimmune pathogenesis, neuronal mechanisms, and somatic mosaicism.
Int J Dermatol
December 2024
Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Vitiligo is a common depigmentation disorder classified into nonsegmental vitiligo (NSV) and segmental vitiligo (SV). SV accounts for 5-27.9% of patients with vitiligo.
View Article and Find Full Text PDFCase series of topical 1.5% ruxolitinib cream for pediatric vitiligo.
JAAD Case Rep
December 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Psychometric Properties and Meaningful Change Thresholds of the Vitiligo Area Scoring Index.
JAMA Dermatol
January 2025
Department of Dermatology, Multicultural Dermatology Center, Henry Ford Health, Detroit, Michigan.
Importance: Defining meaningful improvement using the Total Vitiligo Area Scoring Index (T-VASI) and the Facial VASI (F-VASI) aids interpretation of findings from clinical trials evaluating vitiligo treatments; however, clear and clinically meaningful thresholds have not yet been established.
Objective: To assess concept validity and measurement performance of the T-VASI and F-VASI in patients with nonsegmental vitiligo and to identify meaningful change thresholds.
Design, Settings, And Participants: This mixed-methods study consisted of a secondary analysis of a phase 2 multicenter double-blind dose-ranging randomized clinical trial and embedded qualitative interviews conducted at 35 sites in Canada, France, Japan, and the US.
Biomedical applications of tyrosinases and tyrosinase inhibitors.
Enzymes
September 2024
Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence, Italy. Electronic address:
Article Synopsis
- Tyrosinase is linked to various skin conditions, including both hypopigmentation disorders like vitiligo and hyperpigmentation disorders like melasma, and is also implicated in melanoma progression.
- Current treatments for hyperpigmentation include hydroquinone, azelaic acid, and tretinoin, while new tyrosinase inhibitors are being researched for potential anti-melanoma effects.
- Kojic acid and vitamin C are commonly used in cosmetics to prevent food browning, and bacterial enzymes show promise in biomedical applications, including the production of L-DOPA, a medication for Parkinson’s disease.
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