AI Article Synopsis
- Traumatic spinal cord injury leads to a loss of function due to complex inflammatory processes that result in scarring, known as glial scar.
- This scar consists of various cellular and extracellular components, which complicates its role in tissue repair and recovery.
- Recent reviews focus on understanding the scar's composition, challenging the simplistic view of it as entirely good or bad, and exploring new therapies to improve recovery after spinal injuries.
Article Abstract
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extracellular components. This multidimensional nature should be considered when aiming to understand the role of scarring in limiting tissue repair and recovery. In this Review we discuss recent advances in understanding the composition and phenotypic characteristics of the spinal injury scar, the oversimplification of defining the scar in binary terms as good or bad, and the development of therapeutic approaches to target scar components to enable improved functional outcome after spinal cord injury.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713740 | PMC |
| http://dx.doi.org/10.1038/s41467-019-11707-7 | DOI Listing |
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