A Novel Stimulation Paradigm for Obtaining Interfrequency Amplitude Ratio of Ocular Vestibular Evoked Myogenic Potentials.

Purpose Interfrequency amplitude ratio (IFAR), the ratio of amplitude between ocular vestibular evoked myogenic potentials (oVEMPs) for tone bursts of 500 and 1000 Hz, aids in identification of Ménière's disease with high sensitivity and specificity. However, it requires recording of oVEMP for 2 frequencies, which doubles the time of recording. Use of simultaneous recording of responses for both frequencies could potentially bring down testing time. Simultaneous recording might be possible by modifying the oddball paradigm and using a ratio of 1:1 for the 2 frequencies. This might also reduce variation in oVEMP amplitude between frequencies due to changes in gaze angle between the recordings. However, it remains to be explored whether or not the use of modified oddball paradigm to record oVEMP (MoVEMP) will produce comparable responses to conventional sequential recording of oVEMP (CoVEMP) for obtaining IFAR. Hence, the study aimed to compare MoVEMP and CoVEMP on various measures of oVEMP. Method The study included 29 healthy adults in the age range of 18-30 years, 23 of which were used for validation and 6 for finding test-retest reliability. All participants underwent contralateral oVEMP recording using 500- and 1000-Hz tone bursts presented using MoVEMP and CoVEMP paradigms. Results Comparable outcomes on latencies, amplitude, and IFAR were obtained between CoVEMP and MoVEMP. Furthermore, MoVEMP took significantly lesser time per ear and also produced better test-retest reliability than CoVEMP. Conclusion MoVEMP is a quicker and more reliable clinical stimulation paradigm for obtaining IFAR than CoVEMP.