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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351512 | PMC |
| http://dx.doi.org/10.1097/SLA.0000000000003572 | DOI Listing |
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Pathways to One Health: Enhancing Inter-Sectoral Collaboration in Pakistan.
Ecohealth
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Health Services Academy, Chak Shahzad, Park Road, Islamabad, 44000, Pakistan.
One Health is an integrative approach aiming to achieve optimal health outcomes by recognizing the interconnection between humans, animals, and the environment. This study explores the understanding, perspectives, hurdles, and implications of intersectoral collaboration within Pakistan's human health system, focusing on One Health principles. A qualitative phenomenological approach was employed, involving 17 key informant interviews with purposively selected stakeholders from public health, agriculture, veterinary medicine, agriculture and environmental science.
View Article and Find Full Text PDFAthlete Selective Androgen Receptor Modulators Abuse: A Systematic Review.
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January 2025
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Background: Selective androgen receptor modulators (SARMs) are small-molecule compounds that exert agonist and antagonist effects on androgen receptors in a tissue-specific fashion. Because of their performance-enhancing implications, SARMs are increasingly abused by athletes. To date, SARMs have no Food and Drug Administration approved use, and recent case reports associate the use of SARMs with deleterious effects such as drug-induced liver injury, myocarditis, and tendon rupture.
View Article and Find Full Text PDFSelenium: 48-year journey of global clinical trials.
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Department of Urology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Selenium, an essential trace mineral for health, has seen a rise in clinical trials over the past nearly 5 decades. Our aim here is to provide a comprehensive and concise overview of selenium clinical trials from 1976 to 2023. Overall, the evolution of selenium clinical trials over 48 years has advanced through phases of emergence, prosperity, and either stability or transition.
View Article and Find Full Text PDFEarly investigation of sensorineural hearing loss enables diagnosis of rare metabolic diseases, such as mucopolysaccharidosis type III.
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Audiovestibular Medicine, St George's Hospital, London, UK.
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View Article and Find Full Text PDFPathogenic mechanisms of immune checkpoint inhibitor (ICI)-associated retinal and choroidal adverse reactions.
Am J Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI. Electronic address:
Purpose: To summarize and categorize postulated mechanisms of immune checkpoint inhibitor (ICI)-mediated retinal and choroidal inflammation and discuss resulting implications for evaluation and management of these adverse reactions.
Design: Targeted literature review with interpretation and perspective Methods: We performed a review of selected literature describing immune-mediated retinal and choroidal adverse reactions associated with ICI therapy, synthesizing and categorizing the likely underlying pathogenic mechanisms. Based on these mechanistic categories, we provide perspective on a rational approach to the evaluation of patients with ICI-associated inflammatory disorders of the retina and choroid.
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