An environmentally benign, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides to 2-aminopyridine derivatives using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of ,-dimethylformamide to generate dimethylamine is likely.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648585 | PMC |
| http://dx.doi.org/10.1021/acsomega.9b01031 | DOI Listing |
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