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A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl ketones and I/TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C-C bond cleavage. A simple and high-yielding protocol was developed for the synthesis of a wide range of 1,2-diaryl diketones, which are the backbone for a variety of medicinally important molecules.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648810 | PMC |
| http://dx.doi.org/10.1021/acsomega.9b00833 | DOI Listing |
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