AI Article Synopsis
- This research introduces a new palladium pincer complex that catalyzes carbonylative Sonogashira and Suzuki-Miyaura cross-couplings using a safer solvent, propylene carbonate.
- The pincer complex increases efficiency by allowing reactions to occur at lower palladium loadings of 10 mol %, achieving effective catalytic turnovers.
- Compared to traditional palladium precursors, the pincer complex demonstrates enhanced catalytic activity and robustness, showcasing its potential for sustainable chemical processes.
Article Abstract
This work documents the first palladium pincer complex-catalyzed carbonylative Sonogashira (CS) and carbonylative Suzuki-Miyaura (CSM) cross-coupling. Compared to previous protocols, which employ hazardous and toxic solvents, the aminophosphine pincer complex {[CH-2,6-(NHP{piperidinyl})]Pd(Cl)} () catalyzes both the cross-coupling reactions in propylene carbonate, an eco-friendly and sustainable polar aprotic solvent. Advantageously, employing allows the CS cross-coupling to be carried out at a palladium loading of 10 mol % and the CSM cross-coupling to be carried out at 10 mol %, thus resulting in catalytic turnovers of 10 and 10, respectively. Relative comparison of the pincer complex with conventional palladium precursors Pd(OAc) and PdCl(PPh) shows the efficiency and robustness of the pincer complex in effecting higher catalytic activity at low palladium loadings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648871 | PMC |
| http://dx.doi.org/10.1021/acsomega.8b02886 | DOI Listing |
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