AI Article Synopsis
- - The research introduced a new method for connecting two C-H bonds using palladium catalysts, focusing on reactions between 2-imidazole 1-oxides and compounds like pyrroles and thiophenes.
- - This process successfully created various new 5-heteroarylated 2-imidazole 1-oxides, which are valuable in making bioactive molecules and advanced materials, achieving yields as high as 78%.
- - Additional experiments involving hydrogen/deuterium exchange were conducted to better understand the mechanisms behind this cross-dehydrogenative coupling technique.
Article Abstract
The C(sp)-H bond functionalization methodology was first applied to carry out the palladium-catalyzed oxidative C-H/C-H coupling reactions of 2-imidazole 1-oxides with pyrroles and thiophenes. As a result, a number of novel 5-heteroarylated 2-imidazole 1-oxides, which are of particular interest in the design of bioactive molecules and advanced materials, have been synthesized in yields up to 78%. The detailed H/D-exchange experiments have also been performed to elucidate some mechanistic features of this cross-dehydrogenative coupling process.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648547 | PMC |
| http://dx.doi.org/10.1021/acsomega.8b02916 | DOI Listing |
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