Amphiphilic block polypeptides of poly(sarcosine)--(l- or d-Leu-Aib) (SL12OMe or SD12OMe) and poly(sarcosine)--(l-Leu-Aib) (SL14OMe) were reported to self-assemble into a nanotube morphology. Herein, we tried to construct a phase-separated nanotube by sticking two different kinds of nanotubes. SD12OMe nanotubes were found to stick to SL14OMe nanotubes with a heat treatment at 50 °C, but the sticking yield was limited. The amphiphilic polypeptides were functionalized by replacement of methyl ester with aromatic groups of -ethylcarbazole (SL12Ecz) and naphthalimide (SD12NpiTEG), but they lost the ability to form homogeneous nanotubes. A fraction of the functionalized amphiphilic polypeptides mixing in the nanotube-forming amphiphilic polypeptides, a mixture of SL12OMe and SL12Ecz (9:1) as well as a mixture of SD12OMe and SD12NpiTEG (9:1), allowed nanotube formation. These two kinds of nanotubes partly stuck together with a heat treatment at 15 °C to maintain a segregated state of two kinds of aromatic groups along the nanotube, resulting in the formation of a phase-separated nanotube.
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| http://dx.doi.org/10.1021/acsomega.8b01073 | DOI Listing |
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