Transition Metal- and Oxidant-Free Base-Mediated Selenation of Bicyclic Arenes at Room Temperature.

ACS Omega

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

Published: December 2018

Bicyclic arenyl selenides are of much importance because of their pharmaceutical applications. A simple method for their synthesis has been developed by a reaction of 2-naphthol and styrenyl selenocyanate/diaryl diselenide in the presence of a base at room temperature. The selenation occurs exclusively at the 1-position of 2-naphthol unit. The reactions are relatively fast (2-4 h) and high yielding. A library of substituted naphthyl styrenyl and naphthyl aryl selenides are obtained by this procedure.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643595PMC
http://dx.doi.org/10.1021/acsomega.8b02740DOI Listing

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