AI Article Synopsis
- A new method was developed to synthesize unique aza-diketopiperazines (aza-DKPs) using a combination of reaction techniques.
- The process involves modifying bicyclic aza-DKP structures through reactions like click chemistry, N-acylation, and N-alkylation.
- This approach allows for the efficient creation of a range of original aza-DKPs, enhancing the diversity of aza-heterocyclic compounds.
Article Abstract
Herein, we report a convenient synthesis of unprecedented aza-diketopiperazines (aza-DKPs). The strategy is based on selective diversification of bicyclic aza-DKP scaffolds by click reaction, N-acylation, and/or N-alkylation. These scaffolds containing either azido or amino groups were obtained by a key Rh(I)-catalyzed hydroformylative cyclohydrocarbonylation reaction of allyl-substituted aza-DKP. The methodology is readily amenable to the parallel synthesis of original aza-DKPs to enlarge the chemical diversity of aza-heterocycles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643515 | PMC |
| http://dx.doi.org/10.1021/acsomega.8b01752 | DOI Listing |
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