AI Article Synopsis
- - The study explores the reaction of the platinum complex [PtMe(6-dppd)] with various bromoalkanes (BrCHR), resulting in chiral products via trans oxidative addition, with R representing different hydrogen-bond donor groups like COH and CHB(OH).
- - It examines the formation of isomers from cis oxidative addition and highlights how specific reactions, such as with BrCHCHCOH, predominantly yield certain products, including [PtBrMe(6-dppd)].
- - The research delves into supramolecular chemistry, revealing the influence of various hydrogen bond acceptors (like O, pyridyl N, Br) on the formation of monomers, dimers, or polymers,
Article Abstract
The reaction of [PtMe(6-dppd)], , where 6-dppd is a 1,4-bis(2-pyridyl)pyridazine derivative, with bromoalkanes BrCHR, having a hydrogen-bond donor group R, gave the corresponding chiral products of trans oxidative addition [PtBrMe(CHR)(6-dppd)], , R = COH; , R = 4-CHCOH; , R = 4-CHCHCOH; , R = 2-CHCHOH; , R = 4-CHB(OH); , R = 3-CHB(OH); and , R = 2-CHB(OH). Complex was formed in equilibrium with two isomers formed by cis oxidative addition, while the reaction of with BrCHCHCOH gave mostly [PtBrMe(6-dppd)], . The supramolecular chemistry was studied by structure determination of six of the platinum(IV) complexes, with emphasis on the preference of the hydrogen bond acceptor (O, pyridyl N, or Br atom), formation of monomer, dimer, or polymer, and self-recognition or self-discrimination in self-assembly. Complex formed a monomer with the OH···N hydrogen bond, and complexes and formed racemic dimers by complementary hydrogen bonding with self-discrimination between COH or B(OH) groups, respectively. Complexes , , and formed polymers by intermolecular hydrogen bonding with self-recognition, with containing OH···N and and containing OH···Br hydrogen bonds. It is concluded that there is no clear preference for the hydrogen bond acceptor group, and that the observed product depends also on the orientation of the hydrogen bond donor group.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645029 | PMC |
| http://dx.doi.org/10.1021/acsomega.8b01860 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Organocatalytic Enantioselective Arylation to Access Densely Aryl-Substituted P-Stereogenic Centers.
Org Lett
December 2024
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Although methods for synthesizing chiral phosphorus scaffolds are available, the potential of this molecular chirality remains largely unexplored. Herein, we present a remote desymmetrization of prochiral biaryl phosphine oxides through an organocatalytic asymmetric arylation. This metal-free approach enables the efficient synthesis of a wide range of densely functionalized P(V)-stereogenic compounds with good to excellent yields and satisfactory enantioselectivities.
View Article and Find Full Text PDFPotential Energy Curves of Hydrogen Halides HX(F, Cl, Br) with the -DMFT Method.
J Phys Chem A
December 2024
Institute of atomic and molecular physics, Jilin University, Changchun 130012, China.
The information entropy based on the occupation numbers has been found to play a central role in a description of electron correlation within the density-matrix functional theory [-DMFT, see , 128, 013001]. In this article, the -DMFT method is applied to predict potential energy curves, equilibrium bond lengths, and harmonic vibrational frequencies for the hydrogen halides: HF, HCl, and HBr. The results are compared with other theoretical calculations and experimental spectroscopic data.
View Article and Find Full Text PDFSolvation structure and dynamics of the thiocyanate anion in mixed N,N-Dimethylformamide-water solvents: A molecular dynamics approach.
Chemphyschem
December 2024
University of Ioannina, Chemistry, 45110, Ioannina, GREECE.
The solvation structure and dynamics of the thiocyanate anion at infinite dilution in mixed N, N-Dimethylformamide (DMF)-water liquid solvents was studied using classical molecular dynamics simulation techniques. The results obtained have indicated a preferential solvation of the thiocyanate anions by the water molecules, due to strong hydrogen bonding interactions between the anion and water molecules. A first hydration shell at short intermolecular distances is formed around the SCN- anion consisting mainly by water molecules, followed by a second shell consisting by both DMF and water molecules.
View Article and Find Full Text PDFOne-Pot Synthesis of Multicentric DIL@PDIL Catalyst for Mild CO 2 Conversion to Cyclic Carbonates.
Chemistry
December 2024
Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, 510006, Guangzhou, CHINA.
Among the various studies on CO2 utilization, the sustainable and cost-effective fixation of CO2 into cyclic carbonates remains one of the most intriguing subjects. To this end, a novel type of composite dicationic ionic liquid material, DIL@PDIL, was developed. This composite consists of a dicationic ionic liquid (DIL), DMAP[TMGH]Br, supported on a polymeric dicationic ionic liquid (PDIL), P-DVB/Im[TMGH]Br.
View Article and Find Full Text PDFGuanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.
Angew Chem Int Ed Engl
December 2024
Université de Bordeaux, CBMN UMR5248, IECB, 2, rue Robert Escarpit, 33607, PESSAC, FRANCE.
Peptide stapling has emerged as a versatile approach in drug discovery to reinforce secondary structure elements especially α-helices and improve properties of linear bioactive peptides. Inspired by the prevalence of arginine in protein-protein and protein-DNA interfaces, we investigated guanidinium-stapling as a means to constrain helical peptides. Guanidinium stapling was readily achieved on solid support, utilizing two orthogonally protected lysine or unatural α-amino acid residues with an amino function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!