We describe a simple miniature shake-flask method to measure the octanol-water partition coefficient of an organic compound. Partition between water and octanol is performed in an NMR tube; the aqueous phase is analyzed by H NMR spectroscopy using a benchtop low-field NMR instrument. Neither pre-equilibration of solvents nor isolation of the two phases is required. The procedure is fast and easy enough to be used in a students' laboratory. Scope and limitations as well as possible sources of error are discussed in detail.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644330 | PMC |
| http://dx.doi.org/10.1021/acsomega.7b01102 | DOI Listing |
Publication Analysis
Top Keywords
octanol-water partition
8
partition coefficient
8
coefficient measurement
4
measurement simple
4
nmr
4
simple nmr
4
nmr method
4
method describe
4
describe simple
4
simple miniature
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!