AI Article Synopsis
- Scientists found a way to use ultrasound to help add an amino group to indole compounds in a special liquid called DCM.
- This method works well and can create a variety of useful indole products.
- It can also be used for other similar compounds and makes it easier to get a certain type of alcohol with an amino group.
Article Abstract
Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700257 | PMC |
| http://dx.doi.org/10.3389/fchem.2019.00568 | DOI Listing |
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