AI Article Synopsis
- * The predominant MLVA11 genotype, 116, makes up 86.8% of the strains and suggests a "founder effect," indicating a significant common origin of brucellosis strains in Central Eurasia.
- * The diversity patterns in humans closely resemble those previously seen in animals, which implies that Kazakhstan's brucellosis situation stems from a few introduced lineages that diversified, informing future research directions such as whole genome sequencing and better genotyping methods.
Article Abstract
We describe the genetic diversity of 1327 strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the East Mediterranean group and clustered into 16 MLVA11 genotypes, nine of which are reported for the first time. MLVA11 genotype 116 predominates (86.8%) and is present all over Kazakhstan indicating existence and temporary preservation of a "founder effect" among strains circulating in Central Eurasia. The diversity pattern observed in humans is highly similar to the pattern previously reported in animals. The diversity observed by MLVA suggested that the epidemiological status of brucellosis in Kazakhstan is the result of the introduction of a few lineages, which have subsequently diversified at the most unstable tandem repeat loci. This investigation will allow to select the most relevant strains for testing these hypotheses via whole genome sequencing and to subsequently adjust the genotyping scheme to the Kazakhstan epidemiological situation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700508 | PMC |
| http://dx.doi.org/10.3389/fmicb.2019.01897 | DOI Listing |
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